Nicola Pozzi, Ph.D.
Professor
Biochemistry and Molecular Biology
Research
Molecular mechanisms of thrombosis and immunothrombosis.
Research Interests
In our laboratory, we strive to understand the pathophysiological mechanisms that lead to thrombosis and immunothrombosis, an innate immune response that links coagulation to the recognition, containment and destruction of microbial pathogens. To achieve our goals, we apply a unique combination of biochemistry, protein engineering, X-ray crystallography, single molecule fluorescence biophysics (smFRET and FCS) and surface plasmon resonance (SPR).
Publications
Recent
Rational Design of Protein C Activators
Barranco-Medina S, Murphy M, Pelc L, Chen Z, Di Cera E and Pozzi N
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Molecular mapping of α-thrombin (αT)/β2-glycoprotein I (β2GpI) interaction reveals
how β2GpI affects αT functions
Acquasaliente L, Peterle D, Tescari S, Pozzi N, Pengo V and De Filippis V
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Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent
Induction of Optimal CD8 T Cell Protective Immunity
Eickhoff CS, Zhang X, Vasconcelos JR, Motz RG, Sullivan NL, O’Shea K, Pozzi N, Gohara
DW, Blase JR, Di Cera E and Hoft DF
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Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy
Pozzi N, Bystranowska D, Zuo X and Di Cera E
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Dual effect of histone H4 on prothrombin activation
Pozzi N and Di Cera E
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